Frighted and impatient citizens encountered a myriad of conflicting sources of incomplete information. Therein lay the seeds of another conundrum. The medical profession’s painstaking process of answering these questions by conducting research studies and then implementing evidence-based actions based on the findings was much more time-consuming than expected by the public. What specific risk factors could be identified and how should this knowledge be used to protect the most vulnerable? Who would be struck hardest: persons aged 20–40, as was the case with 1918 influenza, or children, older adults, or the immunocompromised? 1 Which measures would prove most effective in mitigating disease spread in the community? Streamed into Missouri’s hospitals in March 2020, the state’s health care professionals faced a host of critically important and yet unanswered questions:
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